The National Cystic Fibrosis Foundation (CFF) has been the official international philanthropy of the sorority since 1958. It is the recipient of funds raised by the chapters to help because, like all diseases, CF does not discriminate but affects mostly children before the age of two extending to adolescents. . In appreciation of the sorority's efforts, CFF named a research fellowship in honor of Delta Phi Epsilon.

 

Cystic fibrosis is an inherited chronic disease that affects the lungs and digestive system of about 30,000 children and adults in the United States. A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections; it also obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food.

In the 1950's, few children with cystic fibrosis lived to attend elementary school. Today, advances in research and medical treatments have further enhanced and extended life for children and adults with the disease. Many people with cystic fibrosis can now expect to live into their 30s, 40s, and beyond.